The Tata Translational Cancer Research Centre (TTCRC) was established in 2014 with the help of seed funding from Tata Medical Center (TMC) and DBT-Wellcome, India Alliance (Margdarshi Fellowship). In 2016, supported by a grant from Tata Consultancy Services, bespoke laboratories were constructed. TTCRC has been fortunate to recruit and retain highly experienced scientists in the domains of clinical research, genomics and cell biology and the centre has been organised around these individuals. The ecosystem and infrastructure has attracted national and international researchers to come and visit, establish long term collaborations and provide training to enhance the skill mix. At TTCRC, we aim to create an environment for academics, clinicians and industry to work together in close collaboration.